Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Surgical Outcomes of Children with Unilateral Congenital Cataract and Persistent Fetal Vasculature

doi: 10.2147/OPTH.S472028

Figure Lengend Snippet: Retinal images captured by Optical Coherence Tomography (OCT) imaging (Heidelberg Engineering, Heidelberg Engineering GmbH) present a 4-year-old female patient with PFV remnants over disc three years after vitrectomy in left eye (Case 9). The final visual acuity was 0.5–0.63 on Snellen testing (with spectacle correction −7.0). ( A ). 3 D macular OCT image of the left macula shows normal foveal structure. ( B ). In the tomography central retinal thickness was normal 266 µm. ( C ) Papilla HRT image shows PFV stalk remnants inferonasally at 8 o’clock.

Article Snippet: Figure 3 Retinal images captured by Optical Coherence Tomography (OCT) imaging (Heidelberg Engineering, Heidelberg Engineering GmbH) present a 4-year-old female patient with PFV remnants over disc three years after vitrectomy in left eye (Case 9).

Techniques: Tomography, Imaging

Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

doi: 10.2147/OPTH.S242926

Figure Lengend Snippet: Clinical features visible on multimodal imaging of the left eye of a 37-year-old male patient with aCSC. ( A ) Color fundus photograph showing small pigment clustering in the macula and a silhouette of the serous retinal detachment. The arrow indicates the scanning plane, which is depicted on the SD-OCT. ( B ) FAF image at diagnosis showing a speckled (ie, granular) hyper-autofluorescent lesion at the site of the serous neuroretinal detachment. ( C ) FA imaging revealed a single “hot spot” of leakage and a typical small detachment of the RPE above the inferior retinal arcade (arrow). ( D ) An SD-OCT scan at diagnosis revealed SRF accumulation, a thickened choroid, and subretinal debris, presumably consisting of non-phagocytized photoreceptor outer segments. ( E ) SRF resolved spontaneously within a few weeks. ( F ) The areas of hyper-fluorescence on mid-phase ICGA revealed diffuse choroidal hyperpermeability that was larger than the leakage site visible on FA. A recurrent episode 1.5 years later was treated with two subthreshold micropulse diode laser but did not result in resolution of the SRF. Eventually, half-dose photodynamic therapy resulted in resolution of the SRF ( G and H ). At the patient’s final visit 11 months later, hyper-autofluorescent and hypo-autofluorescent abnormalities were visible ( G ), and FA imaging revealed a slightly enlarged area of RPE alterations ( H ). Abbreviations: aCSC, acute central serous chorioretinopathy; ICGA, indocyanine green angiography; FA, Fluorescein angiography; FAF, Fundus autofluorescence; SD-OCT, spectral-domain optical coherence tomography; SRF, subretinal serous fluid; RPE, retinal pigment epithelium.

Article Snippet: These examinations included best-corrected visual acuity (BCVA, measured with a Snellen chart, then converted to ETDRS letters for statistical comparison); slit-lamp examination and/or color fundus photography (Topcon Corp., Tokyo, Japan or Carl Zeiss Meditec AG, Jena, Germany); spectral-domain OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Jena, Germany, OCT-HS100, Canon Inc., Tokyo, Japan, or Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany); fundus autofluorescence imaging (FAF) (Heidelberg Spectralis HRA+OCT or Topcon Corp.); FA (Topcon Corp., Spectralis HRA+OCT, or Carl Zeiss Meditec); and ICGA (Topcon Corp., Heidelberg Spectralis HRA+OCT, or Carl Zeiss Meditec).

Techniques: Imaging, Biomarker Discovery, Fluorescence, Tomography

Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

doi: 10.2147/OPTH.S242926

Figure Lengend Snippet: Clinical features visible on multimodal imaging of the right eye of a 37-year-old female patient ( A – D ) and a 34-year-old male patient ( E – H ) with aCSC. ( A and E ) FA revealed one focal “hot spot” of leakage and no changes in the retinal pigment epithelium. ( B and F ) Despite these circumscribed lesions on FA, ICGA revealed a more widespread area of hyper-fluorescence, which corresponded with multifocal ( B ) or monofocal ( F ) choroidal leakage. ( C and G ) FAF imaging revealed speckled (ie, granular) hyper-autofluorescent changes at the site of serous neuroretinal detachment in both patients, which corresponded with serous retinal detachment visualized on OCT ( D, H ). Abbreviations: aCSC, acute central serous chorioretinopathy; ICGA, indocyanine green angiography; FA, Fluorescein angiography; FAF, Fundus autofluorescence; OCT, optical coherence tomography; SRF, subretinal serous fluid; RPE, retinal pigment epithelium.

Article Snippet: These examinations included best-corrected visual acuity (BCVA, measured with a Snellen chart, then converted to ETDRS letters for statistical comparison); slit-lamp examination and/or color fundus photography (Topcon Corp., Tokyo, Japan or Carl Zeiss Meditec AG, Jena, Germany); spectral-domain OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Jena, Germany, OCT-HS100, Canon Inc., Tokyo, Japan, or Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany); fundus autofluorescence imaging (FAF) (Heidelberg Spectralis HRA+OCT or Topcon Corp.); FA (Topcon Corp., Spectralis HRA+OCT, or Carl Zeiss Meditec); and ICGA (Topcon Corp., Heidelberg Spectralis HRA+OCT, or Carl Zeiss Meditec).

Techniques: Imaging, Fluorescence, Tomography

Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma

doi: 10.2147/OPTH.S343019

Figure Lengend Snippet: Right eye of a mild POAG patient (MD = −4.35). ( A ) The axial scans of the optic nerve head. ( B ) The enhanced depth imaging with spectral-domain optical coherence tomography (EDI-OCT) device (Spectralis, Heidelberg Engineering, Heidelberg, Germany) of lamina cribrosa (LC). ( C ) EDI-OCT assessment of LC showed that: Blue square showing the lamina cribrosa area (0.11 mm 2 ) and the red square prelaminar neural tissue area (0.34 mm 2 ). ( D ) EDI-OCT assessment of LC showed that: yellow line showing LC thickness 93 µm, red line showing prelaminar neural tissue thickness (276 µm), and orange line showing anterior lamina cribrosa surface depth (346 µm). Green line showing reference line connecting both ends of Bruch’s membrane opening.

Article Snippet: Figure 2 Left eye of a mild POAG patient (MD = −5.51). ( A ) The axial scans of the optic nerve head. ( B ) The enhanced depth imaging with spectral-domain optical coherence tomography (EDI-OCT) device (Spectralis, Heidelberg Engineering, Heidelberg, Germany) of lamina cribrosa. ( C ) EDI-OCT assessment of LC showed that: Blue square showing the lamina cribrosa area (0.14 mm ) and the red square prelaminar neural tissue area (0.31 mm ). ( D ) EDI-OCT assessment of LC showed that: yellow line showing LC thickness 96 µm, green line showing prelaminar neural tissue thickness (248 µm), and orange line showing anterior lamina cribrosa surface depth (348 µm).

Techniques: Imaging, Tomography

Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Correlation Between Changes in Lamina Cribrosa Structure and Visual Field in Primary Open-Angle Glaucoma

doi: 10.2147/OPTH.S343019

Figure Lengend Snippet: Left eye of a mild POAG patient (MD = −5.51). ( A ) The axial scans of the optic nerve head. ( B ) The enhanced depth imaging with spectral-domain optical coherence tomography (EDI-OCT) device (Spectralis, Heidelberg Engineering, Heidelberg, Germany) of lamina cribrosa. ( C ) EDI-OCT assessment of LC showed that: Blue square showing the lamina cribrosa area (0.14 mm 2 ) and the red square prelaminar neural tissue area (0.31 mm 2 ). ( D ) EDI-OCT assessment of LC showed that: yellow line showing LC thickness 96 µm, green line showing prelaminar neural tissue thickness (248 µm), and orange line showing anterior lamina cribrosa surface depth (348 µm). Red line showing reference line connecting both ends of Bruch’s membrane opening.

Article Snippet: Figure 2 Left eye of a mild POAG patient (MD = −5.51). ( A ) The axial scans of the optic nerve head. ( B ) The enhanced depth imaging with spectral-domain optical coherence tomography (EDI-OCT) device (Spectralis, Heidelberg Engineering, Heidelberg, Germany) of lamina cribrosa. ( C ) EDI-OCT assessment of LC showed that: Blue square showing the lamina cribrosa area (0.14 mm ) and the red square prelaminar neural tissue area (0.31 mm ). ( D ) EDI-OCT assessment of LC showed that: yellow line showing LC thickness 96 µm, green line showing prelaminar neural tissue thickness (248 µm), and orange line showing anterior lamina cribrosa surface depth (348 µm).

Techniques: Imaging, Tomography